Antiproliferative Effect of Plant-Derived Bioactive Compounds Endowed with Antioxidant Activity on Breast Cancer Cells

Several lines of evidence indicate that plant-derived antioxidant compounds can be used as anticancer agents to support conventional pharmacological therapy. In this context, heme-oxygenase-1 (HO-1) modulation has been proven represent a valid approach for reducing cancer cells’ proliferation through the activation apoptosis and ferroptosis. This study focused on three little studied HO-1 inducers (paeonol, rosolic acid dimethoxy resveratrol) in order evaluate their efficacy antiproliferative breast cells (MCF-7 MDA-MB 231). Cell viability data showed an interesting selectivity resveratrol (DMR) 231 cells. The ineffectiveness Ferrostatin-1 Trolox treatment led exclusion ferroptosis involvement; meanwhile, cell reduction was associated with caspase 3/7 apoptosis. Taken together, our results suggest potential role DMR adjuvant chemotherapy treatment.